Toxicological evaluation of Bauhinia variegata Linn. for estimating the neurological, hematological and physical alterations in the albino mice
Ashwani Kumar
JJT University, Jhunjhunu, Rajasthan and Department of Pharmaceutical Sciences (FMSH), GurukulKangri Vishwavidyalaya, Haridwar
Vikas Anand
Indian SBSPGI Balawala, Dehradun
R.C. Dubey, Kapil K. Goel
Department of Pharmaceutical Sciences (FMSH), Gurukul Kangri Vishwavidyalaya, Haridwar
Abstract
The objective of present study is to establish the safety standards and the evaluation of potential toxicity of Bauhinia variegata Linn. Dried stem bark extract of Bauhinia variegata were evaluated for toxicity studies. For acute toxicity study healthy swiss albino mice, divided in various groups, were administered the sample extract orally in increasing dose. For the sub- acute toxicity studies, the animals of the acute toxicity studies were administered daily for a period of 15 days. The parameters of the acute toxicity studies were tabulated after 48 and 72 hrs of the dose administration and those of the sub acute study were tabulated after 15 days of the dose administration. The toxicity studies did not show any mortality up to a dose of 3000 mg/kg and no significant changes were observed. As no toxicity was observed, Bauhinia variegata Linn. extract could be continued to use in folk medicines.
Bauhinia variegata Linn., acute toxicity, sub acute toxicity
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This work is licensed under a Creative Commons Attribution-Non Commercial- 4.0 International License (CC BY- NC 4.0)
© ASEA
Received: 28.07.2016
Revised:11.10.2016
Accepted: 12.12.2016
First Online: 18.12. 2016
Publisher Name: Action for Sustainable Efficacious Development and Awareness (ASEA)
Print : 0972-3099
Online :2278-5124