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Environment
Conservation Journal

"An International Journal Devoted to Conservation of Environment"

(A PEER REVIEWED/REFEREED JOURNAL)

ISSN: 2278-5124 (Online) :: ISSN: 0972-3099 (Print)

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Environment
Conservation Journal

"An International Journal Devoted to Conservation of Environment"

(A PEER REVIEWED/REFEREED JOURNAL)

ISSN: 2278-5124 (Online) :: ISSN: 0972-3099 (Print)

img3
Environment
Conservation Journal

"An International Journal Devoted to Conservation of Environment"

(A PEER REVIEWED/REFEREED JOURNAL)

ISSN: 2278-5124 (Online) :: ISSN: 0972-3099 (Print)

img4
Environment
Conservation Journal

"An International Journal Devoted to Conservation of Environment"

(A PEER REVIEWED/REFEREED JOURNAL)

ISSN: 2278-5124 (Online) :: ISSN: 0972-3099 (Print)

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Environment
Conservation Journal

"An International Journal Devoted to Conservation of Environment"

(A PEER REVIEWED/REFEREED JOURNAL)

ISSN: 2278-5124 (Online) :: ISSN: 0972-3099 (Print)

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Gastro retentive film of famotidine using bio-material extracted from Sapindus mukrossi fruit pulp

Peeush Singhal

Department of Pharmaceutical Sciences (FAMS), Gurukul Kangri University, Haridwar

Ritu Vishnoi Singhal

Department of Botany, Chinmaya Degree College, Hardwar

 Vijay Kumar Jyoti

Department of Pharmaceutical Sciences, H.N.B. Garhwal Central University, Srinagar, Uttarakhand (India)

 R.D. Kaushik

Department of Chemistry, Gurukul Kangri University,
Haridwar

Anurag Verma

School of Pharmaceutical Sciences, IFTM University, Moradabad – U.P.

Abstract

The present work was based on the development and characterization of gastro retentive dosage form appropriate for controlled release of Famotidine, a drug with narrow therapeutic window. The drug loaded polymer film of biological macromolecules (Sapindus mukrossi) was folded into hard gelatin capsules. The polymeric film revealed a fast release during the first hour followed by a more gradual drug release during a 12-h period following a non-Fickian diffusion process. Tensile strength of polymeric film was optimized using different amount (0.2–0.7 ml) of polyethylene glycol (PEG 400). Various physical parameters were studied for evaluating their performance as a gastroretentive dosage form. Drug and polymers were found to be compatible as revealed by interaction study and scanning electron microscopy (SEM) study revealed uniform dispersion of Famotidine in polymeric matrices. The results indicate that gastro retentive film drug delivery system holds lots of potential for drug having stability problems in alkaline pH or are which mainly absorbed in acidic pH.

Gastro retentive film, Natural gum, Mucoadhesive film, Sapindus mukrossi, Famotidine

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Peeush, S., Singhal, R. V., Jyoti, V. K., Kaushik, R. D., & Anurag, V. (2017). Gastro retentive film of famotidine using bio-material extracted from Sapindus mukrossi fruit pulp. Environment Conservation Journal18(1/2), 173-182.

:https://doi.org/10.36953/ECJ.2017.181224

Received: 28.10.2016

Revised: 21.12.2016

Accepted: 12.02.2017

First Online: 15.06. 2017

:https://doi.org/10.36953/ECJ.2017.181224

MANUSCRIPT STATISTICS

Publisher Name:  Action for Sustainable Efficacious Development and Awareness (ASEA)

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