{"id":3807,"date":"2020-03-30T18:24:53","date_gmt":"2020-03-30T12:54:53","guid":{"rendered":"https:\/\/environcj.in\/?page_id=3807"},"modified":"2020-07-10T22:01:05","modified_gmt":"2020-07-10T16:31:05","slug":"volume-17-issue-3-17318","status":"publish","type":"page","link":"https:\/\/environcj.in\/volume-17-issue-3-17318\/","title":{"rendered":"Volume-17-issue-3\/17318"},"content":{"rendered":"\t\t
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Toxicological evaluation of Bauhinia variegata Linn<\/em>. for estimating the neurological, hematological and physical alterations in the albino mice<\/strong><\/span><\/p>

Ashwani Kumar\u00a0<\/sup><\/strong><\/p>

JJT University, Jhunjhunu, Rajasthan and Department of Pharmaceutical Sciences (FMSH), GurukulKangri Vishwavidyalaya, Haridwar<\/span><\/strong><\/p>

Vikas Anand<\/strong><\/p>

Indian SBSPGI Balawala, Dehradun<\/span><\/strong><\/p>

R.C. Dubey, Kapil K. Goel<\/strong><\/p>

Department of Pharmaceutical Sciences (FMSH), Gurukul Kangri Vishwavidyalaya, Haridwar<\/span><\/strong><\/p><\/div>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Abstract<\/span><\/h1>

The objective of present study is to establish the safety standards and the evaluation of potential toxicity of Bauhinia variegata Linn. Dried stem bark extract of Bauhinia variegata were evaluated for toxicity studies. For acute toxicity study healthy swiss albino mice, divided in various groups, were administered the sample extract orally in increasing dose. For the sub- acute toxicity studies, the animals of the acute toxicity studies were administered daily for a period of 15 days. The parameters of the acute toxicity studies were tabulated after 48 and 72 hrs of the dose administration and those of the sub acute study were tabulated after 15 days of the dose administration. The toxicity studies did not show any mortality up to a dose of 3000 mg\/kg and no significant changes were observed. As no toxicity was observed, Bauhinia variegata Linn. extract could be continued to use in folk medicines.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Bauhinia variegata Linn., acute toxicity, sub acute toxicity<\/em><\/strong><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t

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Hassan A., Rahman S., Deeba F. and Mahmud S., 2009.Antimicrobial activity of some plant extracts having hepatoprotective effect, Journal of Medicinal Plants Research<\/em>., 3, 20-23.<\/p>

Sahu G and Gupta PK, 2012.A review on Bauhinia variegata Linn, International research journal of pharmacy<\/em>, 3, 48-51.<\/p>

Sudheer Kumar K., Seetaramswamy S., Ashok Babu K., and Kishorre Kumar P, 2015.Phytopharmacognostical and isolation of chemical constituents from bauhinia variegata leaf extract,Journal of Pharmacognosy and Phytochemistry,<\/em>4(1), 189-191.<\/p>

Esmail A., Snafi A.2013. Pharmacological importance of Bauhinia variegata : A Review, International journal of Pharma Sciences & research<\/em>, 4(12), 160-164<\/p>

Sahu G., Gupta PK., 2012. A Review on Bauhinia variegata Linn.,International Research Journal of Pharmacy<\/em>, 3(1), 48-51.<\/p>

Patwardhan B., Kalbag D., Patki P.S. and Nagsampagi B.A.,1990. Search of immunomodulatory agents: a review, Indian Drugs<\/em>, 28, 348-358.<\/p>

Ashwani, Sharma PP, Surendra S, Manjusha, Lamba HS., 2011. Analgesic,Antioxidant potential of alcoholic steam bark extract of a Albizialebbek (L.)Benth, Journal of Pharmacy Research <\/em>,4(1):15-18 (2011)<\/p>

Jangra AK, Manjusha, Goel KK, Nautiyal V and Jangra NA., 2012.Anti-inflammatory activity of Albizialebbek (L.)Benthssteam barks extract. Asian journal of chemistry<\/em>,27(7):3259-3260<\/p>

Kumar M., Suba V.,Rammireddy., Babu P., 2015. Acute and subchronic oral toxicity assessment of the ethanolic extract of the root of Oncobaspinosa (Flacourtiaceae) in rodents.Tropical journal of Pharmaceutical research<\/em>. 14(10),1849-1855.<\/p>

Ukwuani AN.,AbubakarMG.,Hassan SW.,Agaie BM., 2012. Toxicological study of hydromethanolic leaves extract of Grewiacrenata. International journal of Pharmaceutical sciences and drug research. 4(4), 245-249.<\/p>

Sadashiv S.,2011. Acute toxicity study for tinosporaCordifolia.International journal of research in Ayurveda & Pharmacy<\/em>, 2(5),1571-1573.<\/p>

Gandhare B.,Kavimani S., Rajkapoor B.,2013. Acute and sub acute toxicity study of methanolic extract of ceibapentandra Linn. Gaertn. On rats, Journal of Scientific Research<\/em>,5(2), 315-324.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Kumar, A., Anand, V., Dubey, R. C., & Goel, K. K. (2016). Toxicological evaluation of Bauhinia variegata Linn. for estimating the neurological, hematological and physical alterations in the albino mice.\u00a0Environment Conservation Journal<\/i>,\u00a017<\/i>(3), 97-102.<\/p>

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\"CreativeThis work is licensed under a Creative Commons Attribution-Non Commercial- 4.0 International License (CC BY- NC 4.0)<\/strong><\/a>\u00a0<\/p>

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Received<\/strong>: 28.07.2016<\/span><\/p>

Revised:<\/strong>11.10.2016<\/p>

Accepted<\/strong>: 12.12.2016<\/span><\/p>

First Online<\/strong>: 18.12. 2016<\/span><\/p>

\"\" https:\/\/doi.org\/10.36953\/ECJ.2016.17318<\/span><\/strong><\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Toxicological evaluation of Bauhinia variegata Linn. for estimating the neurological, hematological and physical alterations in the albino mice Ashwani Kumar\u00a0 JJT University, Jhunjhunu, Rajasthan and Department of Pharmaceutical Sciences (FMSH), GurukulKangri Vishwavidyalaya, Haridwar Vikas Anand Indian SBSPGI Balawala, Dehradun R.C. Dubey, Kapil K. Goel Department of Pharmaceutical Sciences (FMSH), Gurukul Kangri Vishwavidyalaya, Haridwar Abstract The […]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","footnotes":""},"_links":{"self":[{"href":"https:\/\/environcj.in\/wp-json\/wp\/v2\/pages\/3807"}],"collection":[{"href":"https:\/\/environcj.in\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/environcj.in\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/environcj.in\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/environcj.in\/wp-json\/wp\/v2\/comments?post=3807"}],"version-history":[{"count":0,"href":"https:\/\/environcj.in\/wp-json\/wp\/v2\/pages\/3807\/revisions"}],"wp:attachment":[{"href":"https:\/\/environcj.in\/wp-json\/wp\/v2\/media?parent=3807"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}